Nicole (Nikki) Griffin was born on April 16, 1978 in Vicksburg, Mississippi, then later moved to North Carolina.
She attended the New Hanover High School in Wilmington, High School. In High School, she learned about the art of movies in film class from her teacher Marc Matney, who has performed English voice-overs for foreign films showing in the U.S. and England.
She moved out to Los Angeles with a friend so they could both break into show biz. After one month, her friend backed their bags and went back home. However, she came there for a reason, and she was going to stick it out until she made it. She did not make it big at first, but, since she had that beautiful youthful look, she was able to do some acting while breaking into the business.
Her first appearance on television was as an extra on the TV series Dawson's Creek in 2000, but her first real role (although small), was as Liz on the made for TV movie Darktales, also in 2000. She then had other small parts on TV and in the movies, such as in Summer Catch in 2001.
She continued to have small roles up until 2005, when she began to have a reoccurring role as Jesse on the popular TV series, The O.C. Her character on the show is a wild partier and drug addict - the complete opposite of Nikki in real life.
2005 was also a big year for her on the big screen, she had been given the role of Katie Johnson in the 2005 summer blockbuster movie Dukes of Hazzard starring Jessica Simpson, Johnny Knoxville and Seann William Scott, where she plays the beautiful and sexy love interest of both Bo and Luke Duke. She loved working with the cast - and since she has a love of cars, she enjoyed (driving and) riding around in the General Lee.